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Upon testing Imipramine, it was found to yield a significant antidepressant response among depressed individuals.

This lead to a trend of many companies developing tricyclic antidepressants with different three ring structures from Imipramine.

Below is a list of TCAs that affect serotonin and norepinephrine to a similar extent.

Although most affect one neurotransmitter slightly more than the other, differences are considered minimal.

Although some TCAs tend to affect serotonin and norepinephrine equally, some affect one to a significantly greater extent.

Additionally there are others that don’t affect either neurotransmitter to a significant extent; these are listed as “atypical” TCAs.

Tricyclic Antidepressants (TCAs) were developed in the 1950s as a way to treat depression with chemical compounds.

Perhaps the reason why I’m still able to talk to you today and not dead is because I changed from amitriptyline to Cipramil. If I had overdosed and there was a period of one week between overdosing. I think if you’re going to prescribe an antidepressant you should prescribe an SSRI, fluoxetine, Prozac or one of these sooner, and not prescribe tricyclics.

I later found that amitriptyline’s quite toxic, can put you in a coma. I took my overdose then changed from amitriptyline to Cipramil.

Experimentation with derivatives lead to the development of the first TCA drug called “Imipramine.”Initially the drug Imipramine was not intended to treat depressive symptoms, but it was found to induce mania.

This lead researchers to believe that it may have some antidepressant effects.

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