Non sedating antihistamine drug list

Has a low potential for abuse relative to those in schedule 3.

It has a currently accepted medical use in treatment in the United States.

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In severe allergies, such as anaphylaxis or angioedema, these effects may be of life-threatening severity.In type I hypersensitivity allergic reactions, an allergen (a type of antigen) interacts with and cross-links surface Ig E antibodies on mast cells and basophils.Once the allergen cross-links Immunoglobulin E, tyrosine kinases rapidly signal into the cell, leading to cell degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil.Additional administration of epinephrine, often in the form of an autoinjector, is required by people with such hypersensitivities.-antihistamines can be administered topically (through the skin, nose, or eyes) or systemically, based on the nature of the allergic condition.The authors of the American College of Chest Physicians Updates on Cough Guidelines (2006) recommend that, for cough associated with the common cold, first-generation antihistamine-decongestants are more effective than newer, non-sedating antihistamines.

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